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The interactions of p62 as well as the UPS, autophagy and ubiquitinated proteins. Upon UPS inhibition, p62 is upregulated and phosphorylated on S405 and S409, that may facilitate the degradation of ubiquitinated cargoes by using autophagy. p62 synthesis is induced by a rise in Nrf2 adhering to UPS deficiency. The elevated p62 competes with Nrf2 for